As well as being representative of the twin desires of the Soul (the pull to embody vs the pull to return), Pluto rules transformation at a cellular level and hence cellular metabolism, enzyme production and activity, for good or for worse.  It also rules the endocrine system, the elimination system, especially the colon, biological activity, genetics and the reproductive system.  Pluto can strengthen an organ but also cause it to atrophy.  Pluto can affect health negatively or positively through the action of the subconscious mind.